Article
Frequent TERT Promoter Mutations in Ocular Surface Squamous Neoplasia.
Investigative ophthalmology & visual science - 1 Sept 2015
Scholz Simone L, Thomasen Henning, Reis Henning, Möller Inga, Darawsha Raid, Müller Bettina, Dekowski Dirk, Sucker Antje, Schilling Bastian, Schadendorf Dirk, Steuhl Klaus-Peter, Paschen Annette, Westekemper Henrike, Meller Daniel, Griewank Klaus G
Abstract excerpt
PURPOSE: Ocular surface squamous neoplasia, including intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma (SCC), are one of the most common malignant tumors of the conjunctiva. Little is known of the genetic alterations involved in their pathogenesis. Promoter mutations in telomerase reverse transcriptase (TERT) have been identified in various cancers, including many associated with ultraviolet...
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