Article
TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours.
British journal of cancer - 23 Jul 2013
Griewank K G, Murali R, Schilling B, Scholz S, Sucker A, Song M, Süsskind D, Grabellus F, Zimmer L, Hillen U, Steuhl K-P, Schadendorf D, Westekemper H, Zeschnigk M
Abstract excerpt
BACKGROUND: Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for similar mutations. METHODS: The TERT promoter region was analysed by Sanger sequencing in 47 uveal (ciliary body or choroidal) melanomas and 38 conjunctival melanomas. RESULTS: Mutations of the TERT promoter were not identified in uveal melanomas, but were...
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