Article
Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α.
Virology - 20 Dec 2010
Pacheco Beatriz, Finzi Andrés, Stremlau Matthew, Sodroski Joseph
Abstract excerpt
The cross-species transmission of retroviruses is limited by host restriction factors that exhibit inter-species diversity. For example, the TRIM5α proteins of Old World monkeys block the early, post-entry steps in human immunodeficiency virus (HIV-1) infection. We adapted an HIV-1 isolate to replicate in cells expressing TRIM5α(rh) from rhesus monkeys, an Old World species. A single amino acid change in the...
Topics
- Adaptation, Physiological
- Animals
- Capsid Proteins
- Cyclophilin A
- HIV-1
- HeLa Cells
- Humans
- Macaca mulatta
- Models, Molecular
- Multiprotein Complexes
- Mutation
- Proteins