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Article

Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α.

Virology - 20 Dec 2010

Pacheco Beatriz, Finzi Andrés, Stremlau Matthew, Sodroski Joseph

Abstract excerpt

The cross-species transmission of retroviruses is limited by host restriction factors that exhibit inter-species diversity. For example, the TRIM5α proteins of Old World monkeys block the early, post-entry steps in human immunodeficiency virus (HIV-1) infection. We adapted an HIV-1 isolate to replicate in cells expressing TRIM5α(rh) from rhesus monkeys, an Old World species. A single amino acid change in the...

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Identifiers

PMID: 20956011
DOI: 10.1016/j.virol.2010.09.019
PMCID: PMC2975777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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