Article
Demonstration of a novel HIV-1 restriction phenotype from a human T cell line.
PloS one - 30 Jul 2008
Han Yanxing, Wang Xiaojun, Dang Ying, Zheng Yong-Hui
Abstract excerpt
BACKGROUND: Although retroviruses may invade host cells, a productive infection can be established only after the virus counteracts inhibition from different types of host restriction factors. Fv1, APOBEC3G/F, TRIM5alpha, ZAP, and CD317 inhibit the replication of different retroviruses by interfering with viral uncoating, reverse transcription, nuclear import, RNA stability, and release. In humans, although...
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