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Article

Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism.

PLoS pathogens - 1 Jan 2013

Soll Steven J, Wilson Sam J, Kutluay Sebla B, Hatziioannou Theodora, Bieniasz Paul D

Abstract excerpt

Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the development of primate models of HIV-1 infection. Indeed, rhesus macaques are resistant to HIV-1, in part due to restriction imposed by the TRIM5α protein (rhTRIM5α)....

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Source

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Identifiers

PMID: 24086139
DOI: 10.1371/journal.ppat.1003667
PMCID: PMC3784476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism.PMID 24086139Read ↗

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