Article
Naturally Occurring Mutations in HIV-1 CRF01_AE Capsid Affect Viral Sensitivity to Restriction Factors.
AIDS research and human retroviruses - 1 Apr 2018
Nakayama Emi E, Saito Akatsuki, Sultana Tahmina, Jin Zhuan, Nohata Kyotaro, Shibata Masato, Hosoi Miho, Motomura Kazushi, Shioda Tatsuo, Sangkitporn Somchai, Loket Ruangchai, Saeng-Aroon Siriphan
Abstract excerpt
TRIM5α and MxB are known as restriction factors that inhibit the early step of intracellular HIV-1 replication cycle. Both factors are believed to interact with the incoming virus core to suppress HIV-1 infection. The extreme diversity of HIV-1 is thought to be a consequence of its propensity to mutate to escape immune responses and host restriction factors. We recently determined the capsid sequences for 144...
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