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Article

Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders

14 Jun 2015

Abstract excerpt

BACKGROUND: Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes psychiatric symptoms in patients with either Klinefelter syndrome (XXY) or Triple X syndrome (XXX). Over-dosage of some X-linked escapee genes was suggested to cause psychiatric disorders. However, relevance of these rare genetic diseases to the...

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PMID: 26425698
DOI: 10.1016/j.ebiom.2015.06.012

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