Article

Abnormal X Chromosome Inactivation in Females with Major Psychiatric Disorders

2014-09-23

Abstract excerpt

Bipolar disorder, major depression and schizophrenia are severe brain disorders. No biological hallmark has been identified for any of these disorders. Here, we report that abnormal X chromosome inactivation (XCI) often presents in lymphoblastoid cells of female patients with different major psychiatric disorders in the general population. X chromosome inactivation is well preserved in human lymphoblastoid cells....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fef7183-33c0-5307-86ff-04563a5b0c7f
DOI: 10.1101/009555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Abnormal X Chromosome Inactivation in Females with Major Psychiatric DisordersDOI 10.1101/009555Read

Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective DisordersSemantic proximity Read

Defective X Chromosome Inactivation and Cancer Risk in WomenSemantic proximity Read

Defective X-chromosome inactivation and cancer risk in womenSemantic proximity Read

X-chromosome inactivation and its implications for human diseaseSemantic proximity Read

Identification of Intellectual Disability Genes in Female Patients with a Skewed X-Inactivation Pattern.Semantic proximity Read

Skewed X-chromosome inactivation in women with idiopathic intellectual disability as indicative of pathogenic variantsSemantic proximity Read

Skewed X-chromosome Inactivation in Women with Idiopathic Intellectual Disability is Indicative of Pathogenic Variants.Semantic proximity Read

Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder.Semantic proximity Read

Evaluation of the X-chromosome inactivation patterns in females with Gabriele-de Vries syndrome and expansion of clinical spectrumSemantic proximity Read

Skewed X-chromosome Inactivation in Unsolved Neurodevelopmental Disease Cases Can Guide Re-evaluation for X-linked GenesSemantic proximity Read

Pervasive chromatin remodeling at X-inactivation escape genes in schizophrenic malesSemantic proximity Read

X-chromosome inactivation patterns depend on age and tissue but not conception method in humansSemantic proximity Read