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Low <i>XIST</i> expression in Sertoli cells of Klinefelter syndrome patients caused the high susceptibility of these cells to an extra X chromosome

2020-08-27

Abstract excerpt

Klinefelter syndrome (KS) is the most common genetic cause of human male infertility. Patients suffer from heterogeneous testicular atrophy with loss of both germ cells and Sertoli cells. However, the mechanism by which the extra X chromosome causes failure of spermatogenesis remains poorly understood. Here, we profiled testicular single-cell transcriptomes from three KS patients and compared the results with thos...

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Identifiers and source

Literature Corpus work
0218bc9b-5d6b-5178-91bd-d65d52c72237
DOI
10.1101/2020.08.26.269423
Open publication

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Low <i>XIST</i> expression in Sertoli cells of Klinefelter syndrome patients caused the high susceptibility of these cells to an extra X chromosomeDOI 10.1101/2020.08.26.269423
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