Article
Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires.
eLife - 30 Sept 2015
Yang Yang, Wang Chunlin, Yang Qunying, Kantor Aaron B, Chu Hiutung, Ghosn Eliver Eb, Qin Guang, Mazmanian Sarkis K, Han Jian, Herzenberg Leonore A
Abstract excerpt
Processes that define immunoglobulin repertoires are commonly presumed to be the same for all murine B cells. However, studies here that couple high-dimensional FACS sorting with large-scale quantitative IgH deep-sequencing demonstrate that B-1a IgH repertoire differs dramatically from the follicular and marginal zone B cells repertoires and is defined by distinct mechanisms. We track B-1a cells from their early...
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