Article

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation

2020-04-30

Abstract excerpt

In response to antigen challenge, B cells clonally expand, undergo selection and differentiate to produce mature B cell subsets and high affinity antibodies. However, the interplay between dynamic B cell states and their antibody-based selection is challenging to decipher in primary human tissue. We have applied an integrated analysis of bulk and single-cell antibody repertoires paired with single-cell transcripto...

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Literature Corpus work: ac525ab0-359d-5265-9239-5df5b5c71c69
DOI: 10.1101/2020.04.28.054775

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