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Article

Highly sensitive and unbiased approach for elucidating antibody repertoires

27 Jun 2016

Abstract excerpt

Developing B lymphocytes undergo V(D)J recombination to assemble germ-line V, D, and J gene segments into exons that encode the antigen-binding variable region of Ig heavy (H) and light (L) chains. IgH and IgL chains associate to form the B-cell receptor (BCR), which, upon antigen binding, activates B cells to secrete BCR as an antibody. Each of the huge number of clonally independent B cells expresses a unique...

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PMID: 27354528
DOI: 10.1073/pnas.1608649113

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