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Article

Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants.

The Journal of experimental medicine - 9 Jun 2008

Weller Sandra, Mamani-Matsuda Maria, Picard Capucine, Cordier Corinne, Lecoeuche Damiana, Gauthier Frédéric, Weill Jean-Claude, Reynaud Claude-Agnès

Abstract excerpt

T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally...

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Identifiers

PMID: 18519648
DOI: 10.1084/jem.20071555
PMCID: PMC2413031

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Source receipt: pubmed, retrieved 7 Sept 2026.

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