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Article

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

18 Oct 2021

Abstract excerpt

Several human B cell subpopulations are recognised in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and class switch recombination, altogether shaping their immunoglobulin heavy chain (IgH) repertoire. Here, we sequenced the IgH repertoire of naïve, marginal zone,...

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PMID: 34661527
DOI: 10.7554/elife.73111

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