B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.

doi:10.1002/j.1460-2075.1995.tb07157.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.

The EMBO journal - 18 Apr 1995

Tornberg U C, Holmberg D

Abstract excerpt

Analyses of VHDJH rearrangements isolated from murine peritoneal B-1a cells (CD5+, IgMhi, B220lo), peritoneal B-1b cells (CD5-, IgMhi, B220lo), and conventional splenic B cells provide evidence that a unique repertoire of VH regions is displayed by each of these B-cell subsets. The B-1a subset is characterized by a low N-region diversity, by a high frequency of sequence homologies in the VH-D and D-JH junctions,...

Topics

Aging
Animals
B-Lymphocyte Subsets
Base Sequence
Cell Differentiation
Clone Cells
Flow Cytometry
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Genetic Variation
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Peritoneal Cavity

Reading Frames

Selection, Genetic

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 7737121
DOI: 10.1002/j.1460-2075.1995.tb07157.x
PMCID: PMC398261

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7737121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.PMID 7737121Read ↗

Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires.Semantic proximity Read ↗

The Bw cells, a novel B cell population conserved in the whole genus Mus.Semantic proximity Read ↗

Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.Semantic proximity Read ↗

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.Semantic proximity Read ↗

A single VH family and long CDR3s are the targets for hypermutation in bovine immunoglobulin heavy chains.Semantic proximity Read ↗

B Cell Development PathwaysSemantic proximity Read ↗

B-cell development in the amphibian Xenopus.Semantic proximity Read ↗

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.Semantic proximity Read ↗

Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing MiceSemantic proximity Read ↗

Mechanistic and selective constraints act on the establishment of V lambda J lambda junctions in the B cell repertoire.Semantic proximity Read ↗

Characteristics and development of the murine B-1b (Ly-1 B sister) cell population.Semantic proximity Read ↗

Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.