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Article

Severe Nephrotoxic Nephritis following Conditional and Kidney-Specific Knockdown of Stanniocalcin-1.

PloS one - 1 Jan 2015

Huang Luping, Lou Yahuan, Ju Huiming, Zhang Lin, Pan Jenny Szu-Chin, Ross April, Sun Yuxiang, Truong Luan D, Sheikh-Hamad David

Abstract excerpt

BACKGROUND: Inflammation is the hallmark of nephrotoxic nephritis. Stanniocalcin-1 (STC1), a pro-survival factor, inhibits macrophages, stabilizes endothelial barrier function, and diminishes trans-endothelial migration of leukocytes; consistently, transgenic (Tg) overexpression of STC1 protects from nephrotoxic nephritis. Herein, we sought to determine the phenotype of nephrotoxic nephritis after conditional and...

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Identifiers

PMID: 26393521
DOI: 10.1371/journal.pone.0138440
PMCID: PMC4579070

Genes

STC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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