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Article

T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis.

Journal of the American Society of Nephrology : JASN - 1 Mar 2008

Phoon Richard K S, Kitching A Richard, Odobasic Dragana, Jones Lynelle K, Semple Timothy J, Holdsworth Stephen R

Abstract excerpt

T-bet is a transcription factor that is essential for T helper (Th)1 lineage commitment and optimal IFN-gamma production by CD4(+) T cells. We examined the role of T-bet in the development of experimental crescentic glomerulonephritis, which is induced by Th1-predominant, delayed-type hypersensitivity-like responses directed against a nephritogenic antigen. Anti-glomerular basement membrane (GBM)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18235099
DOI: 10.1681/ASN.2007030392
PMCID: PMC2391047

Genes

CCL5
CXCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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