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Article

A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury.

American journal of physiology. Renal physiology - 15 Nov 2015

Hirsch Sara, El-Achkar Tarek, Robbins Lynn, Basta Jeannine, Heitmeier Monique, Nishinakamura Ryuichi, Rauchman Michael

Abstract excerpt

It has been postulated that developmental pathways are reutilized during repair and regeneration after injury, but functional analysis of many genes required for kidney formation has not been performed in the adult organ. Mutations in SALL1 cause Townes-Brocks syndrome (TBS) and nonsyndromic congenital anomalies of the kidney and urinary tract, both of which lead to childhood kidney failure. Sall1 is a...

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Identifiers

PMID: 26311113
DOI: 10.1152/ajprenal.00222.2015

Genes

SALL1

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A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury.PMID 26311113Read ↗

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