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Inducible Podocyte Injury and Proteinuria in Transgenic Zebrafish

24 Mar 2012

Abstract excerpt

Damage or loss of podocytes causes glomerulosclerosis in murine models, and mutations in podocyte-specific genes cause nephrotic syndrome in humans. Zebrafish provide a valuable model for kidney research, but disruption of pronephroi leads to death within a few days, thereby preventing the study of CKD. In this study, we generated an inducible model of podocyte injury in zebrafish (pod::NTR-mCherry) by expressing...

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PMID: 22440901
DOI: 10.1681/asn.2011080776

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