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Article

The swan-neck lesion: proximal tubular adaptation to oxidative stress in nephropathic cystinosis.

American journal of physiology. Renal physiology - 15 May 2015

Galarreta Carolina I, Forbes Michael S, Thornhill Barbara A, Antignac Corinne, Gubler Marie-Claire, Nevo Nathalie, Murphy Michael P, Chevalier Robert L

Abstract excerpt

Cystinosis is an inherited disorder resulting from a mutation in the CTNS gene, causing progressive proximal tubular cell flattening, the so-called swan-neck lesion (SNL), and eventual renal failure. To determine the role of oxidative stress in cystinosis, histologic sections of kidneys from C57BL/6 Ctns(-/-) and wild-type mice were examined by immunohistochemistry and morphometry from 1 wk to 20 mo of age....

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Source

Identifiers

PMID: 25694483
DOI: 10.1152/ajprenal.00591.2014

Genes

CTNS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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