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Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes

11 Oct 2006

Abstract excerpt

The mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) inhibits monocyte chemotactic protein-1- and stromal-derived factor-1alpha (SDF-1alpha)-mediated chemotaxis and diminishes chemokinesis in macrophage-like RAW264.7 and U937 cells in a manner that may involve attenuation of the intracellular calcium signal. STC1 is strongly induced in the kidney following obstructive injury. We...

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PMID: 17032941
DOI: 10.1152/ajprenal.00219.2006

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