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Article

Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney.

Oncogene - 14 May 2015

Pritchett T L, Bader H L, Henderson J, Hsu T

Abstract excerpt

Mutations of the tumor suppressor gene von Hippel-Lindau (VHL) can lead to benign and malignant tumors, including clear-cell renal cell carcinoma (ccRCC). To understand the progression of ccRCC, we generated a novel mouse Vhlh conditional knockout, using Hoxb7-driven Cre that is specific for the collecting ducts and a subset of distal tubules. These mice exhibited wide-spread epithelial disruption and...

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Source

Identifiers

PMID: 25023703
DOI: 10.1038/onc.2014.197

Genes

JAK1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney.PMID 25023703Read ↗

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Formation of Renal Cysts and Tumors in <i>Vhl/Trp53</i> -Deficient Mice Requires HIF1α and HIF2αSemantic proximity Read ↗

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Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis.Semantic proximity Read ↗

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