Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.

PloS one - 1 Jan 2014

Zahedi Kamyar, Barone Sharon, Wang Yang, Murray-Stewart Tracy, Roy-Chaudhury Prabir, Smith Roger D, Casero Robert A, Soleimani Manoocher

Abstract excerpt

BACKGROUND: Expression and activity of spermidine/spermine N1-acetyltransferase (SSAT) increases in kidneys subjected to ischemia/reperfusion (I/R) injury, while its ablation reduces the severity of such injuries. These results suggest that increased SSAT levels contribute to organ injury; however, the role of SSAT specifically expressed in proximal tubule epithelial cells, which are the primary targets of I/R...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Kidney Tubules, Proximal

Share to Neutrophils

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Polyamines

Share to Reperfusion Injury

Source

Open in PubMed Open full text

Identifiers

PMID: 25390069
DOI: 10.1371/journal.pone.0110161
PMCID: PMC4229091

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.PMID 25390069Read ↗

Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.Semantic proximity Read ↗

Immune-mediated Tubule Atrophy Promotes Acute Kidney Injury to Chronic Kidney Disease TransitionSemantic proximity Read ↗

Double-negative T cells have a reparative role after experimental severe ischemic acute kidney injury.Semantic proximity Read ↗

A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury.Semantic proximity Read ↗

Renalase alleviates salt-induced kidney necroptosis and inflammation.Semantic proximity Read ↗

Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injurySemantic proximity Read ↗

A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.Semantic proximity Read ↗

AMD1-Mediated Polyamine Metabolism Governs Tubular Repair Fate by Restraining Senescence after Kidney InjurySemantic proximity Read ↗

Removal of the catalytic subunit of DNA-protein kinase in the proximal tubules promotes DNA and tubular damage during kidney injurySemantic proximity Read ↗

Renoprotective effects of tadalafil on ischemia-reperfusion injury during partial nephrectomy in an animal modelSemantic proximity Read ↗

Epigenetics in acute kidney injurySemantic proximity Read ↗

Blockade of Cysteine Cathepsin Caused Lysosome Dysfunction and Aggravated Adenine-induced Nephropathy by Inducing Tubular Cell SenescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.