Article

TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Fibrosis in Obstructive Kidney Injury

2025-12-31

Abstract excerpt

<h4>ABSTRACT</h4> Capillary regression destabilizes tissue homeostasis and contributes to chronic organ dysfunction, yet the inflammatory pathways that drive pathological vessel loss remain incompletely defined. We previously identified the inflammatory cytokines TNFα and IL-1 as conserved mediators of physiological vessel regression in the neonatal mouse eye, but whether these cytokines contribute to pathologica...

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Literature Corpus work: 07c61a2f-95f5-5ddb-91a6-5a7317c40fbe
DOI: 10.64898/2025.12.30.697039

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