Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2016

Ryan Joanne, Artero Sylvaine, Carrière Isabelle, Maller Jerome J, Meslin Chantal, Ritchie Karen, Ancelin Marie-Laure

Abstract excerpt

A number of genome-wide association studies (GWAS) have investigated risk factors for major depressive disorder (MDD), however there has been little attempt to replicate these findings in population-based studies of depressive symptoms. Variants within three genes, BICC1, PCLO and GRM7 were selected for replication in our study based on the following criteria: they were identified in a prior MDD GWAS study; a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Genotyping Techniques

Share to Neuropeptides

Share to Organ Size

Share to RNA-Binding Proteins

Source

Identifiers

PMID: 26391493
DOI: 10.1016/j.euroneuro.2015.08.022

Genes

PCLO
BICC1
GRM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations.PMID 26391493Read ↗

Effect of genetic variant in BICC1 on functional and structural brain changes in depression.Semantic proximity Read ↗

The PCLO gene and depressive disorders: replication in a population-based study.Semantic proximity Read ↗

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.Semantic proximity Read ↗

A joint study of whole exome sequencing and structural MRI analysis in major depressive disorderSemantic proximity Read ↗

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.Semantic proximity Read ↗

Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766).Semantic proximity Read ↗

[Identification of novel genetic loci associated with major depressive disorder and the hippocampus in a European population using the condFDR method].Semantic proximity Read ↗

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severitySemantic proximity Read ↗

Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.Semantic proximity Read ↗

The genetic basis of major depressive disorder.Semantic proximity Read ↗

PCLO rs2522833-mediated gray matter volume reduction in patients with drug-naive, first-episode major depressive disorder.Semantic proximity Read ↗

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.