Article
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2021
Miles Amy E, Dos Santos Fernanda C, Byrne Enda M, Renteria Miguel E, McIntosh Andrew M, Adams Mark J, Pistis Giorgio, Castelao Enrique, Preisig Martin, Baune Bernhard T, Schubert K Oliver, Lewis Cathryn M, Jones Lisa A, Jones Ian, Uher Rudolf, Smoller Jordan W, Perlis Roy H, Levinson Douglas F, Potash James B, Weissman Myrna M, Shi Jianxin, Lewis Glyn, Penninx Brenda W J H, Boomsma Dorret I, Hamilton Steven P, Sibille Etienne, Hariri Ahmad R, Nikolova Yuliya S
Abstract excerpt
Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational gap, we recently developed a transcriptome-based polygenic risk score (T-PRS) based on common functional variants capturing 'depression-like' shifts in cortical gene expression. Here, we used a non-clinical...
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