Article

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

2021-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Our group developed a transcriptome-based polygenic risk score (T-PRS) that uses common genetic variants to capture ‘depression-like’ shifts in cortical gene expression. Here, we mapped T-PRS onto diagnosis and symptom severity in major depressive disorder (MDD) cases and controls from the Psychiatric Genomics Consortium (PGC). To evaluate potential mechanisms, we further mapped T-PRS onto discre...

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Literature Corpus work: d16679dc-7490-5c23-b5b7-6a901a1f2aee
DOI: 10.1101/2021.02.28.21251786

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