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Article

The genetic basis of major depressive disorder.

Molecular psychiatry - 1 Jun 2023

Flint Jonathan

Abstract excerpt

The genetic dissection of major depressive disorder (MDD) ranks as one of the success stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying 178 genetic risk loci and proposing more than 200 candidate genes. However, the GWAS results derive from the analysis of cohorts in which most cases are diagnosed by minimal phenotyping, a method that has low specificity. I review data...

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PMID: 36702864
DOI: 10.1038/s41380-023-01957-9
PMCID: PMC10611584

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