Article
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
Molecular psychiatry - 1 Apr 2009
Sullivan P F, de Geus E J C, Willemsen G, James M R, Smit J H, Zandbelt T, Arolt V, Baune B T, Blackwood D, Cichon S, Coventry W L, Domschke K, Farmer A, Fava M, Gordon S D, He Q, Heath A C, Heutink P, Holsboer F, Hoogendijk W J, Hottenga J J, Hu Y, Kohli M, Lin D, Lucae S, Macintyre D J, Maier W, McGhee K A, McGuffin P, Montgomery G W, Muir W J, Nolen W A, Nöthen M M, Perlis R H, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit A B, Smoller J W, Tzeng J-Y, van Dyck R, Verhage M, Zitman F G, Martin N G, Wray N R, Boomsma D I, Penninx B W J H
Abstract excerpt
Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network initiative of the US Foundation for the National Institutes of Health, we conducted a genome-wide association study of 435 291 single nucleotide polymorphisms (SNPs) genotyped in 1738 MDD cases and 1802 controls selected to be at low liability for MDD. Of the...
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