PCLO rs2522833-mediated gray matter volume reduction in patients with drug-naive, first-episode major depressive disorder.

doi:10.1038/tp.2017.100

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Article

PCLO rs2522833-mediated gray matter volume reduction in patients with drug-naive, first-episode major depressive disorder.

Translational psychiatry - 30 May 2017

Igata R, Katsuki A, Kakeda S, Watanabe K, Igata N, Hori H, Konishi Y, Atake K, Kawasaki Y, Korogi Y, Yoshimura R

Abstract excerpt

Major depressive disorder (MDD) has been linked to differences in the volume of certain areas of the brain and to variants in the piccolo presynaptic cytomatrix protein (PCLO), but the relationship between PCLO and brain morphology has not been studied. A single-nucleotide polymorphism (SNP) in PCLO, rs2522833, is thought to affect protein stability and the activity of the hypothalamic-pituitary-adrenal axis. We...

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PMID: 28556829
DOI: 10.1038/tp.2017.100
PMCID: PMC5534936

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PCLO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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