Article
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.
Molecular psychiatry - 1 Feb 2026
Shen Xueyi, Toenders Yara J, Han Laura K M, Weihs Antoine, Alexander Nina, Andlauer Till F M, Brosch Katharina, Forstner Andreas J, Grotegerd Dominik, Hahn Tim, Hermesdorf Marco, Hosten Norbert, Jamalabadi Hamidreza, Meinert Susanne, Milaneschi Yuri, Sämann Philipp G, Stein Frederike, Stolicyn Aleks, Teutenberg Lea, Thng Gladi, Adams Mark J, Thomas-Odenthal Florian, Usemann Paula, Völker Uwe, Wittfeld Katharina, Herrera-Rivero Marisol, Jiang Yunxuan, Tian Chao, Groenewold Nynke A, Koopowitz Sheri-Michelle, Strike Lachlan T, Dannlowski Udo, Jansen Andreas, Kircher Tilo, Nenadić Igor, Sim Kang, Straube Benjamin, Völzke Henry, Stein Dan J, Medland Sarah E, Berger Klaus, Grabe Hans J, Krug Axel, McMahon Katie L, de Zubicaray Greig, Pozzi Elena, Veltman Dick J, Thomopoulos Sophia I, Jahanshad Neda, Thompson Paul M, Schmaal Lianne, McIntosh Andrew M, Whalley Heather C
Abstract excerpt
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study analysed data from 11 separate studies, encompassing 50,975 participants from the ENIGMA Major Depressive Disorder Working Group. We developed highly consistent genetic and...
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