Article
Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Aug 2017
Mbarek Hamdi, Milaneschi Yuri, Hottenga Jouke-Jan, Ligthart Lannie, de Geus Eco J C, Ehli Erik A, Willemsen Gonneke, Davies Gareth E, Smit Jan H, Boomsma Dorret I, Penninx Brenda W J H
Abstract excerpt
In 2009, the first genome-wide association study (GWAS) for major depressive disorder (MDD) highlighted an association with PCLO locus on chromosome 7, although not reaching genome-wide significance level. In the present study, we revisited the original GWAS after increasing the overall sample size and the number of interrogated SNPs. In an analysis comparing 1,942 cases with lifetime diagnosis of MDD and 4,565...
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