Article
Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766).
Translational psychiatry - 15 Aug 2017
Wigmore E M, Clarke T-K, Howard D M, Adams M J, Hall L S, Zeng Y, Gibson J, Davies G, Fernandez-Pujals A M, Thomson P A, Hayward C, Smith B H, Hocking L J, Padmanabhan S, Deary I J, Porteous D J, Nicodemus K K, McIntosh A M
Abstract excerpt
Major depressive disorder (MDD) is a heritable and highly debilitating condition. It is commonly associated with subcortical volumetric abnormalities, the most replicated of these being reduced hippocampal volume. Using the most recent published data from Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium's genome-wide association study of regional brain volume, we sought to test whether...
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