Article
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2012
Bermingham Rachel, Carballedo Angela, Lisiecka Danuta, Fagan Andrew, Morris Derek, Fahey Ciara, Donohoe Gary, Meaney James, Gill Michael, Frodl Thomas
Abstract excerpt
Genes and early-life adversity (ELA) interactively increase the risk of developing major depressive disorder (MDD). A recent genome-wide association study suggests that the minor T-allele of single-nucleotide polymorphisms in the bicaudal C homolog 1 gene (BICC1) has a protective role against MDD. The aims of the study were to investigate whether the minor T-allele of BICC1 is protective against hippocampal...
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