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Article

Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) - 1 Jan 2000

Loch Alexandre A, van de Bilt Martinus T, Bio Danielle S, Prado Carolina M do, de Sousa Rafael T, Valiengo Leandro L, Moreno Ricardo A, Zanetti Marcus V, Gattaz Wagner F

Abstract excerpt

OBJECTIVE: To assess the relationship between cognitive function, a proposed schizophrenia endophenotype, and two genetic polymorphisms related to dopamine function, catechol-O-methyl transferase (COMT) Val158Met and dopamine receptor 3 (DRD3) Ser9Gly. METHODS: Fifty-eight outpatients with schizophrenia/schizoaffective disorder and 88 healthy controls underwent neurocognitive testing and genotyping. Analyses of...

Read the complete abstract on PubMed

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Real-Time Polymerase Chain Reaction

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Source

Identifiers

PMID: 26376054
DOI: 10.1590/1516-4446-2014-1553

Genes

COMT
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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