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Article

COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jun 2013

Heinzel Sebastian, Dresler Thomas, Baehne Christina G, Heine Monika, Boreatti-Hümmer Andrea, Jacob Christian P, Renner Tobias J, Reif Andreas, Lesch Klaus-Peter, Fallgatter Andreas J, Ehlis Ann-Christine

Abstract excerpt

The prefrontal cortex plays a major role in cognitive control, but it is unclear how single genes and gene-gene interactions (genetic epistasis) impact neural and behavioral phenotypes. Both dopamine (DA) availability ("inverted U-model") and excitatory versus inhibitory DA receptor stimulation ("dual-state theory") have been linked to important principles of prefrontal processing. Catechol-O-methyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22617852
DOI: 10.1093/cercor/bhs132

Genes

COMT
DRD4

Provenance

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