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Article

Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.

Biological psychiatry - 1 Jan 2008

Diaz-Asper Catherine M, Goldberg Terry E, Kolachana Bhaskar S, Straub Richard E, Egan Michael F, Weinberger Daniel R

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affect dopamine regulated prefrontal cortical activity during working memory (WM) tasks, and to weakly increase risk for developing schizophrenia. Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large...

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Identifiers

PMID: 17707347
DOI: 10.1016/j.biopsych.2007.03.031
PMCID: PMC3708610

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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