Article
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2009
Prata Diana P, Mechelli Andrea, Fu Cynthia H Y, Picchioni Marco, Toulopoulou Timothea, Bramon Elvira, Walshe Muriel, Murray Robin M, Collier David A, McGuire Philip
Abstract excerpt
Dopamine has a crucial role in the modulation of neurocognitive function, and synaptic dopamine activity is normally regulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT). Perturbed dopamine function is a key pathophysiological feature of schizophrenia. Our objectives were (i) to examine epistasis between the DAT 3' UTR variable number of tandem repeats (VNTR) and COMT Val158Met...
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