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Article

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.

Schizophrenia research - 1 Oct 2014

Twamley Elizabeth W, Hua Jessica P Y, Burton Cynthia Z, Vella Lea, Chinh Kelly, Bilder Robert M, Kelsoe John R

Abstract excerpt

Cognitive and functional impairments are core features of schizophrenia. This study examined the catechol-O-methyltransferase (COMT) genotype and its relationship to cognition and functional capacity in 188 individuals with schizophrenia or schizoaffective disorder. We found that in a dose-response fashion, individuals with more Met alleles performed significantly better on tests of learning/memory and...

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Source

Identifiers

PMID: 25139113
DOI: 10.1016/j.schres.2014.07.041

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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