Article
Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.
Human genetics - 1 Feb 2007
Nicodemus Kristin K, Kolachana Bhaskar S, Vakkalanka Radhakrishna, Straub Richard E, Giegling Ina, Egan Michael F, Rujescu Dan, Weinberger Daniel R
Abstract excerpt
Catechol-O-methyltransferase (COMT) regulates dopamine degradation and is located in a genomic region that is deleted in a syndrome associated with psychosis, making it a promising candidate gene for schizophrenia. COMT also has been shown to influence prefrontal cortex processing efficiency. Prefrontal processing dysfunction is a common finding in schizophrenia, and a background of inefficient processing may...
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