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Article

Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity.

Translational psychiatry - 4 Feb 2014

Vercammen A, Weickert C S, Skilleter A J, Lenroot R, Schofield P R, Weickert T W

Abstract excerpt

Individual changes in dopamine-related genes influence prefrontal activity during cognitive-affective processes; however, the extent to which common genetic variations combine to influence prefrontal activity is unknown. We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD2) G-T (rs2283265) single nucleotide polymorphisms and functional magnetic resonance imaging...

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Identifiers

PMID: 24495967
DOI: 10.1038/tp.2013.125
PMCID: PMC3944629

Genes

COMT
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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