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Article

Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex.

Biological psychiatry - 15 May 2011

Nixon Devon C, Prust Morgan J, Sambataro Fabio, Tan Hao-Yang, Mattay Venkata S, Weinberger Daniel R, Callicott Joseph H

Abstract excerpt

BACKGROUND: Accumulating evidence indicates that genetic polymorphisms of D-amino acid oxidase activator (DAOA) (M24; rs1421292; T-allele) and catechol-O-methyltransferase (COMT) (Val¹⁵⁸Met; rs4680) likely enhance susceptibility to schizophrenia. Previously, clinical association between DAOA M24 (T-allele) and a functionally inefficient 3-marker COMT haplotype (that included COMT Val¹⁵⁸Met) uncovered epistatic...

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Source

Identifiers

PMID: 21215384
DOI: 10.1016/j.biopsych.2010.10.031

Genes

COMT
DAOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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