Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.

Journal of psychiatry & neuroscience : JPN - 1 Nov 2013

Ira Elisa, Zanoni Martina, Ruggeri Mirella, Dazzan Paola, Tosato Sarah

Abstract excerpt

BACKGROUND: Endophenotypes in genetic psychiatry may increase our understanding of the molecular mechanisms underlying disease risk and its manifestations. We sought to investigate the link between neuropsychological impairments and brain structural abnormalities associated with the COMT Val(158)Met polymorphism in patients with schizophrenia to improve understanding of the pathophysiology of this disorder....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrophy
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endophenotypes

Share to Frontal Lobe

Share to Neuropsychological Tests

Share to Psychomotor Performance

Share to Schizophrenic Psychology

Share to Temporal Lobe

Source

Open in PubMed Open full text

Identifiers

PMID: 23527885
DOI: 10.1503/jpn.120178
PMCID: PMC3819150

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.PMID 23527885Read ↗

[Schizophrenia, genetics and cognition].Semantic proximity Read ↗

Are brain structural abnormalities useful as endophenotypes in schizophrenia?Semantic proximity Read ↗

Endophenotypes in schizophrenia: a selective review.Semantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.Semantic proximity Read ↗

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.Semantic proximity Read ↗

Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential.Semantic proximity Read ↗

Prefrontal neurons and the genetics of schizophrenia.Semantic proximity Read ↗

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.Semantic proximity Read ↗

Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?Semantic proximity Read ↗

Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.