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Article

DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008

Bombin Igor, Arango Celso, Mayoral María, Castro-Fornieles Josefina, Gonzalez-Pinto Ana, Gonzalez-Gomez Cristina, Moreno Dolores, Parellada Mara, Baeza Inmaculada, Graell Montserrat, Otero Soraya, Saiz Pilar A, Patiño-Garcia Ana

Abstract excerpt

Catechol-O-methyltransferase (COMT) and dopamine receptors 2 (DRD2) and 3 (DRD3) have been associated with a higher risk of developing psychosis and with dopaminergic system (DAS) regulation. Frontal cognitive functioning has been proven to be a useful endophenotype for psychosis and it is partially controlled by the DAS. Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms...

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Source

Identifiers

PMID: 18351593
DOI: 10.1002/ajmg.b.30710

Genes

COMT
DRD2
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.PMID 18351593Read ↗

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