Article
COMT rs4680 and DAOA rs947267 Polymorphism Interact to Influence Cognition and Psychiatric Symptoms in Chronic Schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2026
Chen Pinhong, Wang Lubin, Wang Fuqiang, Xu Wenhao, Wang Dongmei, Xiu Meihong, Chen Dachun, Lackey Blake, Wu Hanjing E, Zhang Xiangyang
Abstract excerpt
Dopaminergic and glutamatergic dysfunction, involving genes such as COMT and DAOA, is implicated in schizophrenia. However, large-scale studies examining their interactions on cognitive and symptomatic outcomes remain scarce. COMT rs4680 and DAOA rs947267 polymorphisms were measured in chronic schizophrenics (n = 758) and controls (n = 416), and cognition and psychiatric symptoms were assessed using the...
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