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Article

Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.

Developmental biology - 15 Oct 2015

Shin Eun Hae, Zhao Guannan, Wang Qian, Lovicu Frank J

Abstract excerpt

Sprouty proteins function as negative regulators of the receptor tyrosine kinase (RTK)-mediated Ras/Raf/MAPK pathway in many varied physiological and developmental processes, inhibiting growth factor-induced cellular proliferation, migration and differentiation. Like other negative regulators, Sprouty proteins are expressed in various organs during development, including the eye; ubiquitously expressed in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26375880
DOI: 10.1016/j.ydbio.2015.09.005

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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