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Article

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10

14 Jan 2010

Abstract excerpt

GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans. Furthermore, many other mutant genes that cause renal agenesis exert their effects via the GDNF/RET pathway. Therefore, RET signaling is believed to play a central role in renal organogenesis. Here, we re-examine the extent to which the functions of...

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PMID: 20084103
DOI: 10.1371/journal.pgen.1000809

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Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10PMID 20084103Read ↗

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Development of the urogenital system is regulated via the 3′UTR of GDNFSemantic proximity Read ↗

SOX9 controls epithelial branching by activating RET effector genes during kidney developmentSemantic proximity Read ↗

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A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.Semantic proximity Read ↗

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