Article
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.
Development (Cambridge, England) - 1 Oct 1999
Minowada G, Jarvis L A, Chi C L, Neubüser A, Sun X, Hacohen N, Krasnow M A, Martin G R
Abstract excerpt
The Drosophila sprouty gene encodes an antagonist of FGF and EGF signaling whose expression is induced by the signaling pathways that it inhibits. Here we describe a family of vertebrate Sprouty homologs and demonstrate that the regulatory relationship with FGF pathways has been conserved. In bot...
Topics
- Amino Acid Sequence
- Animals
- Chick Embryo
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Evolution, Molecular
- Extremities
- Female
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental