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Article

Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.

Development (Cambridge, England) - 1 Apr 2010

Pan Yi, Carbe Christian, Powers Andrea, Feng Gen-Sheng, Zhang Xin

Abstract excerpt

Shp2/Ptpn11 tyrosine phosphatase is a general regulator of the RTK pathways. By genetic ablation, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, survival and differentiation. Shp2 deletion disrupted ERK signaling and cell cycle regulation, which could be partially compensated by activated Kras signaling, confirming that Ras signaling was the main downstream target of...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Intracellular Signaling Peptides and Proteins

Share to Lens, Crystalline

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 20215346
DOI: 10.1242/dev.042820
PMCID: PMC2835324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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