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Article

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.

Developmental cell - 1 Feb 2005

Basson M Albert, Akbulut Simge, Watson-Johnson Judy, Simon Ruth, Carroll Thomas J, Shakya Reena, Gross Isabelle, Martin Gail R, Lufkin Thomas, McMahon Andrew P, Wilson Patricia D, Costantini Frank D, Mason Ivor J, Licht Jonathan D

Abstract excerpt

Intercellular signaling molecules and their receptors, whose expression must be tightly regulated in time and space, coordinate organogenesis. Regulators of intracellular signaling pathways provide an additional level of control. Here we report that loss of the receptor tyrosine kinase (RTK) antagonist, Sprouty1 (Spry1), causes defects in kidney development in mice. Spry1(-/-) embryos have supernumerary ureteric...

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Source

Identifiers

PMID: 15691764
DOI: 10.1016/j.devcel.2004.12.004

Genes

GDNF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.PMID 15691764Read ↗

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10Semantic proximity Read ↗

Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.Semantic proximity Read ↗

Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.Semantic proximity Read ↗

Nephron progenitor maintenance is controlled through FGFs and Sprouty1 InteractionSemantic proximity Read ↗

A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.Semantic proximity Read ↗

Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.Semantic proximity Read ↗

Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1Semantic proximity Read ↗

Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.Semantic proximity Read ↗

Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.Semantic proximity Read ↗

Development of the urogenital system is regulated via the 3′UTR of GDNFSemantic proximity Read ↗

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.Semantic proximity Read ↗

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.Semantic proximity Read ↗

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